![]() ![]() RNA structures dimerization polymerization reaction mechanism reactive intermediates. Tutorials Find tutorials from novice to expert to help you expand your skills. User Manual Get quick answers and step-by-step instructions. Here we review the discovery of this unexpected intermediate, and the chemical, kinetic, and structural evidence for its role in template copying chemistry. Creativity Substance 3D Modeler Learn & support Get Started Install, learn the basics, and start your first project. Surprisingly, this simple model has turned out to be incorrect, and the dominant pathway has now been shown to involve the reaction of two activated nucleotides with each other to form a 5'-5'-imidazolium bridged dinucleotide intermediate. The mechanism by which the primer becomes extended by one nucleotide was assumed to be a classical in-line nucleophilic-substitution reaction in which the 3'-hydroxyl of the primer attacks the phosphate of the incoming activated monomer with displacement of the imidazole leaving group. An important model for the study of nonenzymatic template copying, which would be a key part of any such pathway, involves the reaction of ribonucleoside-5'-phosphorimidazolides with an RNA primer/template complex. The emergence of the replication of RNA oligonucleotides was a critical step in the origin of life.
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